Abstract | BACKGROUND: METHODS: Patients with perennial allergies (149 patients) were selected. The control group included 156 healthy people. Genotypes were evaluated via polymerase chain reaction and restriction fragment length polymorphism, using the Alw26I restriction enzyme. RESULTS: There was no significant difference between groups in the proportions of the Ile/Ile (wild type) and Ile/Val (heterozygote) genotypes. However, the Val/Val (mutant type homozygote) was expressed in only one case (0.7%) in the perennial allergic rhinitis group, as compared with 11 cases (7.1%) in the controls (p < 0.05). CONCLUSION: Our results indicate that the Val/Val genetic polymorphism of GSTP1 may exert some protective effects in allergic inflammation.
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Authors | Yoo-Sam Chung, Heung-Eog Cha, Il-Gyu Kang, You-Jin Hwang, Seon-Tae Kim |
Journal | American journal of rhinology
(Am J Rhinol)
2006 Nov-Dec
Vol. 20
Issue 6
Pg. 648-51
ISSN: 1050-6586 [Print] United States |
PMID | 17181111
(Publication Type: Journal Article)
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Chemical References |
- DNA
- Glutathione S-Transferase pi
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Topics |
- Adolescent
- Adult
- DNA
(genetics)
- Female
- Genotype
- Glutathione S-Transferase pi
(genetics)
- Humans
- Korea
- Male
- Middle Aged
- Oxidative Stress
(genetics)
- Polymerase Chain Reaction
- Polymorphism, Genetic
- Retrospective Studies
- Rhinitis, Allergic, Perennial
(enzymology, genetics)
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