Immunohistochemical studies of chromogranins (A and C) in pituitary adenomas.

Abstract

Expression of Chromogranin A and C was examined immunohistochemically on 45 surgically obtained pituitary adenomas. Positive rate of chromogranin A was 40.0% and chromogranin C was positive in 8.0% of 45 pituitary adenomas. Chromogranin A was expressed frequently in adenomas in which at least one of the FSH alpha, FSH beta, LH beta and TSH beta subunits was positive. It also expressed frequently in non-functioning adenomas. The positive rate of chromogranin A was low in GH or PRL positive adenomas. These findings suggest that chromogranin could be a parameter of the functional differentiation of the pituitary adenomas.

• Authors: K Oda, K Inada, R Y Osamura
• Journal: Pathology, research and practice (Pathol Res Pract) Vol. 187 Issue 5 Pg. 626-8 (Jun 1991) ISSN: 0344-0338 [Print] Germany
• PMID: 1717962 (Publication Type: Journal Article)

Chemical References

• Chromogranin A
• Chromogranins
• Gonadotropins
• Proteins
• Prolactin
• Thyrotropin
• Growth Hormone

Topics

• Adenoma (metabolism, physiopathology)
• Chromogranin A
• Chromogranins (metabolism)
• Gonadotropins (metabolism)
• Growth Hormone (metabolism)
• Humans
• Immunohistochemistry
• Pituitary Neoplasms (metabolism, physiopathology)
• Prolactin (metabolism)
• Proteins
• Staining and Labeling
• Thyrotropin (metabolism)