Successful bone marrow transplantation in an 8-month-old patient with chronic granulomatous disease.

Abstract

An eight-month-old boy with chronic granulomatous disease (CGD) received HLA identical sibling bone marrow transplantation (BMT) following busulphan and cyclophosphamide conditioning. No graft-versus-host disease was demonstrated. Five years after transplantation, mixed chimerism was 60% in peripheral blood, and 85% of his neutrophils had normal oxidative burst activity. He is now six years old, in very good health and growing well. In this period, he experienced no severe infectious diseases. To our knowledge, this is the first case of CGD who had BMT in Turkey. His successful outcome illustrates that BMT in a patient with CGD in the first years of life should be considered early if an HLA-matched donor is already available, before development of any recurrent life-threatening infections or irreversible organ damage.

• Authors: Savaş Kansoy, Necil Kütükçüler, Serap Aksoylar, Güzide Aksu, Mehmet Kantar, Nazan Cetingül
• Journal: The Turkish journal of pediatrics (Turk J Pediatr) 2006 Jul-Sep Vol. 48 Issue 3 Pg. 253-5 ISSN: 0041-4301 [Print] Turkey
• PMID: 17172071 (Publication Type: Case Reports, Journal Article)

Topics

• Bone Marrow Transplantation
• Granulomatous Disease, Chronic (therapy)
• Humans
• Infant
• Male