[Expression of BDNF and trk B in the cochleas of the aged rats].

Abstract

OBJECTIVE:

To explore the correlation between the expression of brain derived neurotrophic factor (BDNF) and presbycusis in the cochleae of the aged rats.

METHOD:

The mRNA expression of BDNF and presbycusis in the cochleas of the aged rats was quantitated by real time PCR.

RESULT:

The expression of BDNF in the cochleas of the aged rats with presbycusis was obviously less than that in the control group. And the difference was statistically significant.

CONCLUSION:

The expression of BDNF is closely correlated to presbycusis in the aged rats.

• Authors: Yuru Li, Delong Liu, Yuanyuan Zhang, Ping Wang, Baodong Du
• Journal: Lin chuang er bi yan hou ke za zhi = Journal of clinical otorhinolaryngology (Lin Chuang Er Bi Yan Hou Ke Za Zhi) Vol. 20 Issue 19 Pg. 894-5 (Oct 2006) China
• PMID: 17168119 (Publication Type: English Abstract, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Brain-Derived Neurotrophic Factor
• Receptor, trkB

Topics

• Aging
• Animals
• Brain-Derived Neurotrophic Factor (metabolism)
• Cochlea (metabolism)
• Rats
• Rats, Wistar
• Receptor, trkB (metabolism)