Abstract | BACKGROUND: Infectious complications are the main cause of late death in patients with acute pancreatitis. Routine prophylactic antibiotic use following a severe attack has been proposed but remains controversial. On the other hand, nutritional support has recently yielded promising clinical results. The aim of study was to compare enteral vs. parenteral feeding for prevention of infectious complications in patients with predicted severe acute pancreatitis. METHODS: RESULTS: The incidence of pancreatic infectious complications (infected pancreatic necrosis, pancreatic abscess) was significantly lower in the enterally fed group (7 vs. 16, p = 0.02). In the TEN group, 7 patients developed multiple organ failure whereas 17 parenterally fed patients developed multiple organ failure (p = 0.02). Overall mortality was 20% with two deaths in the TEN group and twelve in the TPN group (p < 0.01). CONCLUSION:
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Authors | Maxim S Petrov, Mikhail V Kukosh, Nikolay V Emelyanov |
Journal | Digestive surgery
(Dig Surg)
Vol. 23
Issue 5-6
Pg. 336-44; discussion 344-5
( 2006)
ISSN: 0253-4886 [Print] Switzerland |
PMID | 17164546
(Publication Type: Comparative Study, Journal Article, Randomized Controlled Trial)
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Copyright | Copyright 2006 S. Karger AG, Basel. |
Chemical References |
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Topics |
- APACHE
- Abscess
(etiology)
- Acute Disease
- Adult
- Aged
- Analysis of Variance
- C-Reactive Protein
(metabolism)
- Enteral Nutrition
- Female
- Humans
- Infections
(etiology)
- Male
- Middle Aged
- Necrosis
- Pancreatitis
(complications, therapy)
- Parenteral Nutrition
- Prognosis
- Treatment Outcome
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