Abstract |
The results of the treatment of the syndrome of disseminated intravascular coagulopathy ( DIC) in 41 patients with liver cirrhosis are reported. A relation between the severity of the liver impairment and the degree of the increase of the fibrin split products (FSP) was established. FSP above 100 micrograms/ml were found in patients with III class liver failure according to Child-Turcotte-Pugh and rating above 6.5 according to Z. KrÅstev. The administration of 30,000-60,000 U of the protease inhibitor contrykal led to mastering of the hemorrhagic diathesis in 19 of 21 patients (group A). The increased FSP in the serum fell (chi 2 = 5.79; p less than 0.001). In contrast, the administration of PAMBA and styptanon did not affect the hemorrhagic diathesis and DIC syndrome in 16 of 20 other patients (group B--chi 3 = 20.54; p less than 0.001). The authors recommend protease inhibitors as the treatment of choice of DIC syndrome in liver cirrhosis. Only in case of lack of effect should heparin be added.
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Authors | L Mateva, O Donkova |
Journal | Vutreshni bolesti
(Vutr Boles)
Vol. 30
Issue 2
Pg. 105-10
( 1991)
ISSN: 0506-2772 [Print] Bulgaria |
Vernacular Title | Lechenie s proteazni inkhibitori na sindroma na diseminirana intravazalna koagulatsiia pri bolni s chernodrobna tsiroza. |
PMID | 1716395
(Publication Type: Comparative Study, English Abstract, Journal Article)
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Chemical References |
- Antifibrinolytic Agents
- Protease Inhibitors
- para-Aminobenzoates
- 4-aminomethylbenzoic acid
- Aprotinin
- estriol succinate
- Estriol
- 4-Aminobenzoic Acid
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Topics |
- 4-Aminobenzoic Acid
(therapeutic use)
- Antifibrinolytic Agents
(therapeutic use)
- Aprotinin
(therapeutic use)
- Disseminated Intravascular Coagulation
(drug therapy, etiology)
- Drug Evaluation
- Estriol
(therapeutic use)
- Humans
- Liver Cirrhosis
(complications, drug therapy)
- Protease Inhibitors
(therapeutic use)
- para-Aminobenzoates
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