[Clinical investigation: the intraocular pressure-lowering efficacy and safety of brinzolamide combined with betaxolol].

Abstract

PURPOSE:

To evaluate the intraocular pressure (IOP) lowering efficacy and safety of Brinzolamide combined with Betaxolol for the Chinese glaucomatous patients.

METHODS:

Twenty-six glaucoma patients (44 eyes) diagnosed as primary open angle glaucoma, ocular hypertension and remnant glaucoma (IOP remained high after antiglaucomatous surgeries) were recruited as a research team. After a washing out phase, Brinzolamide 1% combined with Betaxolol 0.25% were administered to them twice daily [(8 +/- 1) o'clock in the morning and (20 +/- 1) o'clock in the evening] respectively. The observing duration was 2 months. The IOP and the side effect before and after the administration of the eyedrops were observed.

RESULTS:

The average IOP lowering ranged from 5.03 mm Hg to 6.65 mm Hg (1 mm Hg = 0.133 kPa) (20.55% to 37.30%) after the administration of Brinzolamide 1% combined with Betamolol 0.25% twice a day. The IOP lowering effect was stable and the patients complained little uncomfortable.

CONCLUSIONS:

Brinzolamide combined with Betaxolol has significant IOP lowering effect and few side effect for the Chinese people. Brinzolamide can be used as the main medication for the treatment of glaucoma.

• Authors: Yu Minbin, Min Fang, Jian Ge, Shengsong Huang
• Journal: Yan ke xue bao = Eye science (Yan Ke Xue Bao) Vol. 21 Issue 4 Pg. 137-40, 152 (Dec 2005) ISSN: 1000-4432 [Print] China
• PMID: 17162869 (Publication Type: English Abstract, Journal Article)

Chemical References

• Antihypertensive Agents
• Carbonic Anhydrase Inhibitors
• Ophthalmic Solutions
• Sulfonamides
• Thiazines
• brinzolamide
• Betaxolol

Topics

• Adolescent
• Adult
• Aged
• Antihypertensive Agents (administration & dosage)
• Betaxolol (administration & dosage)
• Carbonic Anhydrase Inhibitors (administration & dosage)
• Female
• Glaucoma (drug therapy)
• Humans
• Intraocular Pressure (drug effects)
• Male
• Middle Aged
• Ophthalmic Solutions
• Sulfonamides (administration & dosage)
• Thiazines (administration & dosage)
• Tonometry, Ocular