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New findings from the Bipolar Collaborative Network: clinical implications for therapeutics.

Abstract
In this article, we highlight recent Bipolar Collaborative Network data. We found that childhood-onset bipolar illness is common, often goes untreated for more than a decade, and carries a poor prognosis. During randomized studies of adjunctive medications in depression: 1) Venlafaxine showed higher switch rates than bupropion or sertraline; 2) Tranylcypromine was as well tolerated as lamotrigine; and 3) Modafinil was more effective than placebo. Finally, in treatment of overweight and obesity, topiramate and sibutramine showed equal efficacy but poor tolerability, and zonisamide data showed that it may be useful for mood and weight loss.
AuthorsRobert M Post, Lori L Altshuler, Mark A Frye, Trisha Suppes, Susan McElroy, Paul E Keck Jr, Gabriele S Leverich, Ralph Kupka, Willem A Nolen, Heinz Grunze
JournalCurrent psychiatry reports (Curr Psychiatry Rep) Vol. 8 Issue 6 Pg. 489-97 (Dec 2006) ISSN: 1523-3812 [Print] United States
PMID17162830 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)
Chemical References
  • Anticonvulsants
  • Antidepressive Agents
  • Antimanic Agents
Topics
  • Adult
  • Anticonvulsants (adverse effects, therapeutic use)
  • Antidepressive Agents (adverse effects, therapeutic use)
  • Antimanic Agents (adverse effects, therapeutic use)
  • Bipolar Disorder (diagnosis, drug therapy, psychology)
  • Child
  • Depressive Disorder, Major (diagnosis, drug therapy, psychology)
  • Diagnosis, Differential
  • Humans
  • Prognosis

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