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Rapid clearance of Lyme disease spirochetes lacking OspC from skin.

Abstract
We previously demonstrated that Borrelia burgdorferi requires OspC to colonize a mammalian host. To delineate this requirement, we analyzed the clearance of ospC mutant spirochetes and found that they were eliminated within 48 h. We conclude that B. burgdorferi uses OspC to resist innate host defenses immediately after transmission.
AuthorsKit Tilly, Aaron Bestor, Mollie W Jewett, Patricia Rosa
JournalInfection and immunity (Infect Immun) Vol. 75 Issue 3 Pg. 1517-9 (Mar 2007) ISSN: 0019-9567 [Print] United States
PMID17158906 (Publication Type: Journal Article, Research Support, N.I.H., Intramural)
Chemical References
  • Antigens, Bacterial
  • Bacterial Outer Membrane Proteins
  • OspC protein
Topics
  • Animals
  • Antigens, Bacterial (genetics)
  • Bacterial Outer Membrane Proteins (genetics)
  • Borrelia burgdorferi (genetics, growth & development, immunology)
  • Gene Deletion
  • Immunity, Innate (genetics)
  • Lyme Disease (immunology, microbiology, transmission)
  • Mice
  • Mice, Inbred C3H
  • Skin Diseases, Bacterial (immunology, microbiology, transmission)

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