Dopamine beta-hydroxylase gene (DbetaH) -1021C-->T influences self-reported paranoia during cocaine self-administration.

Abstract

BACKGROUND:

Variation in the gene for dopamine beta-hydroxylase (DbetaH) has been reported to associate with cocaine-induced paranoia as assessed by retrospective self-report. This association has yet to be tested prospectively.

METHODS:

Visual analog scale (VAS) ratings of paranoia were obtained in 31 cocaine users during three cocaine self-administration sessions (8, 16, and 32 mg/70 kg). Pharmacogenetic interactions between cocaine and a putative functional polymorphism in DbetaH (-1021C-->T) were assessed.

RESULTS:

VAS self-ratings showed significant or trend-level interactions of genotype and time during each session (p = .004, .09 and .003, respectively) with TT homozygotes endorsing greater paranoia over time than either CT or CC individuals. Interactions were significant at all doses in African Americans (n = 19; p = .02, .04 and .05). No other demographic or experimental variable distinguished genotypic groups.

CONCLUSIONS:

Results indicate that individuals homozygous for the 'very low-activity' T allele at DbetaH -1021C-->T show an increased propensity to paranoia over time during cocaine self-administration.

• Authors: Rasmon Kalayasiri, Atapol Sughondhabirom, Ralitza Gueorguieva, Vladimir Coric, Wendy J Lynch, Jaakko Lappalainen, Joel Gelernter, Joseph F Cubells, Robert T Malison
• Journal: Biological psychiatry (Biol Psychiatry) Vol. 61 Issue 11 Pg. 1310-3 (Jun 01 2007) ISSN: 0006-3223 [Print] United States
• PMID: 17157269 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)

Chemical References

• Dopamine beta-Hydroxylase
• Cocaine

Topics

• Adult
• Alleles
• Cocaine (administration & dosage)
• Cocaine-Related Disorders (genetics, psychology)
• Dopamine beta-Hydroxylase (genetics)
• Female
• Genotype
• Humans
• Infusions, Intravenous
• Male
• Middle Aged
• Paranoid Disorders (chemically induced, genetics, psychology)
• Polymorphism, Genetic (genetics)
• Prospective Studies
• Reinforcement Schedule