Abstract |
The aim of this study was to assess the behavior of the diastolic left ventricular (LV) filling pattern and cardiac hypertrophy after treatment with cilazapril. Twelve patients (9 male and 3 female) with mild to moderate essential hypertension, aged 46 +/- 14.1 years, were treated with cilazapril for 1 year. They underwent Doppler echocardiography at the beginning (I), after 6 months (II), and after 1 year (III) of treatment. The following parameters were evaluated: mean arterial pressure (MAP) automatically recorded for 24 h, interventricular septal and posterior wall thickness, LV and end-diastolic diameter, LV mass index, early (E) and late (A) diastolic filling flow velocities, and the ratio E/A. A significant reduction in LV hypertrophy and an improved diastolic filling pattern of the left ventricle was shown after 6 months of therapy with cilazapril; this improvement still remained after 1 year of therapy.
|
Authors | W Haberbosch, R De Simone, R Dietz, W Waas, H Tillmanns, W Kübler |
Journal | Journal of cardiovascular pharmacology
(J Cardiovasc Pharmacol)
Vol. 17 Suppl 2
Pg. S159-62
( 1991)
ISSN: 0160-2446 [Print] United States |
PMID | 1715471
(Publication Type: Journal Article)
|
Chemical References |
- Angiotensin-Converting Enzyme Inhibitors
- Pyridazines
- Cilazapril
|
Topics |
- Adult
- Aged
- Angiotensin-Converting Enzyme Inhibitors
(therapeutic use)
- Blood Pressure
(drug effects)
- Cardiomegaly
(drug therapy)
- Cilazapril
- Echocardiography, Doppler
- Female
- Heart Rate
(drug effects)
- Humans
- Hypertension
(drug therapy)
- Male
- Middle Aged
- Pyridazines
(therapeutic use)
- Ventricular Function
(drug effects)
|