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[Treatment with inorganic iodine for Graves' hyperthyroidism].

Abstract
Nowadays, patients with Graves' hyperthyroidism are initially treated with methimazole or propylthiouracil. Several serious adverse reactions like agranulocytosis are caused by these drugs. Inorganic iodine decreases serum thyroid hormone concentrations in patients with Graves' hyperthyroidism without adverse reaction, but this effect usually continues only a limited time. However, a virtually complete remission or longstanding euthyroid state may be obtained with inorganic iodine therapy alone in patients with mild Graves' disease, who show small thyroid volume and low TRAb titers. Inorganic iodine therapy may become one of the treatment methods in the patients with mild Graves' hyperthyroidism.
AuthorsJaeduk Yoshimura Noh, Toshiko Chino, Koichi Ito
JournalNihon rinsho. Japanese journal of clinical medicine (Nihon Rinsho) Vol. 64 Issue 12 Pg. 2269-73 (Dec 2006) ISSN: 0047-1852 [Print] Japan
PMID17154090 (Publication Type: Journal Article, Review)
Chemical References
  • Antithyroid Agents
  • Autoantibodies
  • Immunoglobulins, Thyroid-Stimulating
  • Iodides
  • Symporters
  • thyrotropin-binding inhibitory immunoglobulin
  • sodium-iodide symporter
Topics
  • Animals
  • Antithyroid Agents (adverse effects)
  • Autoantibodies (blood)
  • Female
  • Graves Disease (blood, drug therapy, pathology)
  • Humans
  • Immunoglobulins, Thyroid-Stimulating
  • Iodides (administration & dosage, metabolism)
  • Pregnancy
  • Remission Induction
  • Severity of Illness Index
  • Symporters (metabolism, physiology)
  • Thyroid Gland (metabolism, pathology)

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