Role of selective arterial secretin injection test in treatment of gastrinoma.

Abstract

BACKGROUND/AIMS:

To study whether use of the selective arterial secretin injection test increased the rate of tumor localization and curative resection in patients with gastrinoma.

METHODOLOGY:

Nine patients with gastrinoma were divided into 2 groups, before and after introduction of selective arterial secretin injection test; 4 patients before 1987 (Group 1) and 5 patients after 1988 (Group 2). Clinical results were compared retrospectively between groups.

RESULTS:

Localization of primary gastrinoma was made with conventional imaging studies in 1 of the 4 patients in Group 1 and 3 of the 5 patients in Group 2. In contrast, use of the selective arterial secretin injection test was able to localize the primary tumor in 4 of the 5 patients in Group 2. Total gastrectomy was carried out in the 4 patients in Group 1, and pancreatoduodenectomy was the most frequently performed procedure (3 patients) in Group 2. Rate of curative resection was 25% and 80% in Groups 1 and 2, respectively.

CONCLUSIONS:

These results indicate that combining selective arterial secretin injection test with conventional imaging studies contributes to increasing rate of curative resection of gastrinoma.

• Authors: Chikashi Shibata, Yuji Funayama, Kouhei Fukushima, Ken-Ichi Takahashi, Tatsuya Ueno, Munenori Nagao, Sho Haneda, Kazuhiro Watanabe, Katsuyoshi Kudoh, Atsushi Kohyama, Hiroo Naito, Iwao Sasaki
• Journal: Hepato-gastroenterology (Hepatogastroenterology) 2006 Nov-Dec Vol. 53 Issue 72 Pg. 960-3 ISSN: 0172-6390 [Print] Greece
• PMID: 17153463 (Publication Type: Journal Article)

Chemical References

• Secretin

Topics

• Adult
• Diagnostic Imaging
• Female
• Gastrinoma (diagnosis, surgery)
• Humans
• Injections, Intra-Arterial
• Male
• Middle Aged
• Pancreatic Function Tests
• Pancreatic Neoplasms (diagnosis, surgery)
• Prognosis
• Secretin (administration & dosage)
• Treatment Outcome