Hyponatremia, hypophosphatemia, and hypouricemia in a girl with macrophage activation syndrome.

Abstract

Macrophage activation syndrome, a life-threatening complication of rheumatic disorders, is accompanied by the overproduction of cytokines. We describe a girl with macrophage activation syndrome complicating systemic-onset juvenile arthritis who developed hyponatremia, hypophosphatemia, and hypouricemia associated with a high level of serum tumor necrosis factor alpha. Renal proximal tubule dysfunction was considered to be the cause, which may be attributable to tumor necrosis factor alpha.

• Authors: Kazuki Yamazawa, Kazuki Kodo, Jun Maeda, Sayu Omori, Mariko Hida, Tetsuya Mori, Midori Awazu
• Journal: Pediatrics (Pediatrics) Vol. 118 Issue 6 Pg. 2557-60 (Dec 2006) ISSN: 1098-4275 [Electronic] United States
• PMID: 17142545 (Publication Type: Case Reports, Journal Article)

Chemical References

• Uric Acid

Topics

• Female
• Humans
• Hyponatremia (etiology)
• Hypophosphatemia (etiology)
• Infant
• Macrophage Activation
• Metabolic Diseases (blood, etiology)
• Syndrome
• Uric Acid (blood)