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Circulating adhesion molecules during kidney allograft reperfusion.

Abstract
Adhesion molecule expression is an important event during early transplant failure. The aim of the present study was to examine the release of adhesion molecules during the first minutes of kidney allograft reperfusion in relation to delayed graft function and acute graft rejection. We enrolled 49 renal transplant recipients, including 13 cases of delayed graft function (DGF) and 11 cases of acute graft rejection (AR). Plasma concentrations of E-selectin, VCAM-1 and ICAM-1 after 3 min of reperfusion were significantly higher than in the iliac vein before reperfusion. There was no statistically significant difference between patients with and without DGF as regards E-selectin, VCAM-1 and ICAM-1 concentrations in the iliac vein before and in the renal vein after 3 min of reperfusion. Concentrations of adhesion molecules in the iliac vein before reperfusion and in the renal vein after 3 min of reperfusion did not differ significantly between patients with and without AR except for ICAM-1 iliac vein concentration which was significantly increased in AR patients. Plasma levels of E-selectin, ICAM-1 and VCAM-1 were increased after kidney allograft reperfusion. Moreover, elevated serum levels of ICAM-1 before transplantation correlated with subsequent acute kidney allograft rejection. The results suggest that elevated ICAM-1 levels may be implicated in acute graft rejection.
AuthorsL Domański, M Gryczman, A Pawlik, M Sulikowski, M Romanowski, M Ostrowski, M Myślak, J Rózański, K Safranow, G Dutkiewicz, K Ciechanowski
JournalTransplant immunology (Transpl Immunol) Vol. 16 Issue 3-4 Pg. 172-5 (Nov 2006) ISSN: 0966-3274 [Print] Netherlands
PMID17138050 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Cell Adhesion Molecules
Topics
  • Cell Adhesion Molecules (blood)
  • Delayed Graft Function (blood)
  • Enzyme-Linked Immunosorbent Assay
  • Female
  • Graft Rejection (blood)
  • Humans
  • Kidney (blood supply)
  • Kidney Transplantation
  • Male
  • Middle Aged
  • Reperfusion
  • Transplantation, Homologous

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