Abstract | BACKGROUND: METHODS: Patients with fluid overloading and hypoalbuminemia who needed diuretic treatment were enrolled and were divided into 2 groups: the first group having clearance of creatinine (CCr) >20 ml/min, and the second group having CCr < or = 20 ml/min. FU (60 mg) mixed with HA (HA group), 60 mg FU mixed with FFP (FFP group) and water (placebo group) were given intravenously to these patients for 60 minutes in random order on the first, third and fifth day. After drug administration, 8-hour urine was collected, and urine amount and urinary sodium excretion were checked. RESULTS: Both the HA group and the FFP group had significantly higher urinary volume and sodium excretion than the placebo group in the patients with CCr >20 ml/min or CCr < or = 20 ml/min (p < 0.01). In the patients with CCr >20 ml/min, there was no difference in the amount of urine excretion and cumulative urinary sodium excretion between the HA group and FFP group. In the patients with CCr < or =ml;20 ml/min, the HA group had a significantly higher urine output and urinary sodium excretion than the FFP group (p < 0.05). CONCLUSIONS: In ICU patients, 60 mg FU mixed with HA or FFP has a similar diuretic effect in patients with CCr >20 ml/min. FFP is an effective alternative choice for improving diuresis for ICU patients with hypoalbuminemia. In patients with CCr < or = 20 ml/min, albumin mixed with 60 mg FU has a superior diuretic effect compared with FFP mixed with FU.
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Authors | Chien-Wei Hsu, Shoa-Lin Lin, Shu-Fen Sun, Kuo-An Chu, Hsiao-Min Chung, Hsueh-Wen Chang |
Journal | Journal of nephrology
(J Nephrol)
2006 Sep-Oct
Vol. 19
Issue 5
Pg. 621-7
ISSN: 1121-8428 [Print] Italy |
PMID | 17136691
(Publication Type: Comparative Study, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Chemical References |
- Diuretics
- Serum Albumin
- Furosemide
- Sodium
- Creatinine
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Topics |
- Adult
- Creatinine
(urine)
- Cross-Over Studies
- Diuresis
(drug effects)
- Diuretics
(administration & dosage)
- Drug Resistance
(drug effects)
- Female
- Furosemide
(administration & dosage)
- Humans
- Hypoalbuminemia
(therapy, urine)
- Intensive Care Units
- Male
- Plasma
- Prospective Studies
- Serum Albumin
(administration & dosage)
- Single-Blind Method
- Sodium
(urine)
- Time Factors
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