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Human papilloma virus in hyperplastic tonsillar and adenoid tissues in children.

AbstractBACKGROUND:
Human papillomavirus (HPV) in childhood causes skin and anogenital warts as well as the recurrent respiratory papillomatosis, a life-threatening cause of upper airway obstruction in children. To date, the information on HPV infection in tonsillar and adenoid hyperplasia in children is limited.
PURPOSE:
The purpose of this study was to investigate the presence of HPV DNA in children with benign tonsillar and/or adenoid hyperplasia.
METHODS:
One hundred six samples of paraffin-embedded adenoid and/or tonsillar tissues from 102 children, 57 girls and 45 boys (age range, 2-14 years), were tested for the presence of HPV DNA using polymerase chain reaction (PCR) with general primers GP5+/GP6+. HPV typing was performed by PCR with specific primers for HPV-16, -18, -33 and -11.
RESULTS:
HPV DNA was detected in 9 (8.5%) of the 106 collected specimens. The frequencies of HPV typing were 6 of 9 (66.7%) for HPV-16, 2 of 9 (22.2%) for HPV-11, zero of 9 (0%) for HPV-33 and HPV-18, whereas one HPV-positive sample remained untyped. No multiple HPV infection was detected. HPV was detected in 6 (9.4%) children with tonsillar hyperplasia and in 3 (7.1%) with adenoid hyperplasia. The mean age of children with HPV-positive specimens was lower than that of HPV-negative children (P = 0.006). No statistical correlation in the prevalence of HPV infection was observed according to children's sex, origin or residence (urban or rural).
CONCLUSION:
Although the significance of the presence of HPV DNA in tonsillar and adenoid hyperplasias remains obscure, the PCR detection of high-risk HPV DNA should be evaluated cautiously.
AuthorsIoannis N Mammas, George Sourvinos, Catherine Michael, Demetrios A Spandidos
JournalThe Pediatric infectious disease journal (Pediatr Infect Dis J) Vol. 25 Issue 12 Pg. 1158-62 (Dec 2006) ISSN: 0891-3668 [Print] United States
PMID17133162 (Publication Type: Journal Article)
Chemical References
  • DNA Primers
  • DNA, Viral
Topics
  • Adenoids (virology)
  • Adolescent
  • Age Factors
  • Child
  • Child, Preschool
  • DNA Primers
  • DNA, Viral (analysis)
  • Female
  • Humans
  • Hyperplasia (virology)
  • Male
  • Palatine Tonsil (pathology, virology)
  • Papillomaviridae (classification, genetics, isolation & purification)
  • Papillomavirus Infections (virology)
  • Paraffin Embedding
  • Polymerase Chain Reaction
  • Residence Characteristics
  • Sex Factors
  • Statistics as Topic

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