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Urinary 8-oxodeoxyguanosine, aflatoxin B1 exposure and hepatitis B virus infection and hepatocellular carcinoma in Taiwan.

Abstract
To evaluate the role of oxidative stress and aflatoxin exposure on risk of hepatocellular carcinoma (HCC), a case-control study nested within a community-based cohort was conducted in Taiwan. Baseline urine samples, collected from a total of 74 HCC cases and 290 matched controls, were used to determine by enzyme-linked immunosorbent assays the level of urinary excretion of 8-oxodeoxyguanosine (8-oxodG), a biomarker of oxidative DNA damage and urinary aflatoxin B(1) metabolites, a biomarker of aflatoxin exposure. Multivariate-adjusted linear regression analysis showed that urinary aflatoxin metabolites and gender were significantly associated with level of urinary 8-oxodG among controls. Moreover, after adjustments for potential confounding factors, there was a statistically significant positive dose-response relationship between levels of urinary 8-oxodG and urinary aflatoxin metabolites (P < 0.0001). However, when compared with subjects in the lowest quartile of 8-oxodG, there was a decrease in risk of HCC, with adjusted odds ratios (ORs) of 0.8 [95% confidence interval (CI) 0.3-2.0], 0.7 (95% CI 0.3-2.0) and 0.7 (95% CI 0.2-1.7) for subjects in the second, third and fourth quartile, respectively. The combination of level of urinary 8-oxodG below the median and hepatitis B virus infection resulted in an OR of 11.4 (95% CI 3.9-33.3), compared with those with urinary 8-oxodG above the median and hepatitis B virus surface antigen negative. These results suggest that elevated levels of urinary 8-oxodG may be related to increasing level of aflatoxin exposure but may also indicate enhanced repair of oxidative DNA damage and therefore lower risk of HCC.
AuthorsHui-Chen Wu, Qiao Wang, Lian-Wen Wang, Hwai-I Yang, Habibul Ahsan, Wei-Yann Tsai, Li-Yu Wang, Shu-Yuan Chen, Chien-Jen Chen, Regina M Santella
JournalCarcinogenesis (Carcinogenesis) Vol. 28 Issue 5 Pg. 995-9 (May 2007) ISSN: 0143-3334 [Print] England
PMID17127712 (Publication Type: Journal Article, Research Support, N.I.H., Extramural)
Chemical References
  • 8-oxodeoxyadenosine triphosphate
  • Deoxyadenine Nucleotides
  • Aflatoxin B1
Topics
  • Adult
  • Aflatoxin B1 (toxicity, urine)
  • Carcinoma, Hepatocellular (etiology)
  • Case-Control Studies
  • Cohort Studies
  • DNA Damage
  • Deoxyadenine Nucleotides (urine)
  • Female
  • Hepatitis B (complications)
  • Humans
  • Liver Neoplasms (etiology)
  • Male
  • Middle Aged
  • Oxidative Stress
  • Risk
  • Sex Factors
  • Taiwan

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