The
diacylglycerol (DAG), a commonly used as a cooking oil in Japan, results in a lower elevation of serum
triglyceride (TG) after ingestion compared to
triacylglycerol (TAG). Postprandial
hyperlipidemia (PPHL) and an increase in remnant
lipoproteins (RLP) levels are risk factors for CAD, and a close relationship between PPHL and
type 2 diabetes and/or
insulin resistance has been reported. To evaluate the effect of DAG on PPHL in
insulin resistance and
glucose intolerance, 11 subjects with a normal
glucose tolerance (NGT) and 14 subjects with IGT received oral fat tolerance test (OFTT) twice. They ingested emulsified test
oils prepared with either DAG or TAG. In the IGT subjects, after the DAG and TAG load, the serum concentrations of TG, RLP-TG, and RLP-
cholesterol increased throughout the 4-h study. The responses of these variables above baseline after the DAG load were significantly smaller than those after the TAG load (p<0.05). In contrast, in the NGT subjects, changes in these parameters were much smaller than those observed for IGT subjects. The difference in the integrated responses for serum RLP-
cholesterol concentration during OFTT between DAG and TAG in all subjects can be easily explained by the integrated response of
insulin rather than
glucose during oral
glucose tolerance test (r=0.7, p<0.01). DAG was more effective in
insulin resistant and hyperinsulinemic participants regardless of
glucose intolerance, and may be beneficial in reducing the extent of CAD risk in such individuals.