Abstract |
The present study investigated the effects of Kamikihi-to ( KKT), a Kampo medicine, on impairment of spatial memory in rats using an eight-arm radial maze task. Scopolamine (0.5 mg/kg, i.p.), a non-selective muscarinic receptor antagonist, and Delta(9)-tetrahydrocannabinol ( THC; 6 mg/kg, i.p.), a principal psychoactive component of marihuana, each markedly impaired the spatial memory. KKT (1 and 3 mg/kg, p.o.) significantly improved the scopolamine-induced impairment of spatial memory. KKT (30 mg/kg, p.o.) also improved significantly the THC-induced impairment of spatial memory. Moreover, KKT (3 and 30 mg/kg, p.o.) enhanced tremors induced by oxotremorine, a muscarinic M(1) receptor agonist. Taken together these findings suggest that KKT is a useful drug for treating memory deficits.
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Authors | Nobuaki Egashira, Naomi Manome, Kouji Kurauchi, Yoshiaki Matsumoto, Katsunori Iwasaki, Kenichi Mishima, Yukihiro Shoyama, Michihiro Fujiwara |
Journal | Phytotherapy research : PTR
(Phytother Res)
Vol. 21
Issue 2
Pg. 126-9
(Feb 2007)
ISSN: 0951-418X [Print] England |
PMID | 17117451
(Publication Type: Journal Article)
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Copyright | Copyright (c) 2006 John Wiley & Sons, Ltd. |
Chemical References |
- Drugs, Chinese Herbal
- kamikihi-to
- Oxotremorine
- Dronabinol
- Scopolamine
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Topics |
- Animals
- Dronabinol
(pharmacology)
- Drugs, Chinese Herbal
(pharmacology, therapeutic use)
- Male
- Maze Learning
(drug effects)
- Medicine, Kampo
- Memory
(drug effects)
- Memory Disorders
(chemically induced, drug therapy)
- Mice
- Mice, Inbred Strains
- Oxotremorine
(pharmacology)
- Rats
- Rats, Wistar
- Scopolamine
(pharmacology)
- Tremor
(chemically induced)
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