Targeting lipoxygenases with care.

Abstract	Though fish oils possess cardio-protective, anti-inflammatory, and anti-cancer properties, their molecular and biochemical mechanism of action is lacking. In this issue of Chemistry & Biology, Tjonahen and colleagues identify a new metabolite of eicosapentanoic acid, resolvin E2, produced by 5-lipoxygenase.
Authors	Patricia M de Souza, Justine Newson, Derek W Gilroy
Journal	Chemistry & biology (Chem Biol) Vol. 13 Issue 11 Pg. 1121-2 (Nov 2006) ISSN: 1074-5521 [Print] United States
PMID	17113992 (Publication Type: Journal Article, Comment)
Chemical References	Anti-Inflammatory Agents resolvin E2 Eicosapentaenoic Acid Arachidonate 5-Lipoxygenase 5S,12R,18R-trihydroxy-6Z,8E,10E,14Z,16E-eicosapentaenoic acid
Topics	Animals Anti-Inflammatory Agents (metabolism, pharmacology) Arachidonate 5-Lipoxygenase (metabolism) Eicosapentaenoic Acid (analogs & derivatives, biosynthesis, metabolism, pharmacology) Humans Neutrophils (drug effects, immunology, metabolism) Peritonitis (drug therapy, immunology)

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