A potential therapeutic strategy for inhibition of corneal neovascularization with new anti-VEGF agents.

The factors triggering corneal neovascularization involve various growth factors. The data supporting a causal role for vascular endothelial growth factor (VEGF) in corneal neovascularization are extensive. One possible strategy for treating corneal neovascularization is to inhibit VEGF activity by competitively binding VEGF with a specific neutralizing anti-VEGF antibody. The vireo-retinal service in the recent years enjoyed a high level of success in managing choroidal neovascularization using anti-VEGF strategies. Efficacy and tolerability have been demonstrated for drugs targeting VEGF. We herein hypothesize that topical application of new anti-VEGF agents such as pegaptanib, ranibizumab and bevacizumab are potentially useful for inhibiting corneal neovascularization and restoration of corneal clarity. Further investigations are needed to place these medical treatments alongside corneal neovascularization therapeutics.
AuthorsHamid Hosseini, Mahmood Nejabat
JournalMedical hypotheses (Med Hypotheses) Vol. 68 Issue 4 Pg. 799-801 ( 2007) ISSN: 0306-9877 [Print] Scotland
PMID17107753 (Publication Type: Journal Article)
Chemical References
  • Angiogenesis Inhibitors
  • Vascular Endothelial Growth Factor A
  • Angiogenesis Inhibitors (pharmacology)
  • Animals
  • Binding, Competitive
  • Cornea (blood supply)
  • Corneal Neovascularization (drug therapy, pathology)
  • Humans
  • Inflammation
  • Models, Biological
  • Models, Cardiovascular
  • Models, Theoretical
  • Retinal Vessels (pathology)
  • Vascular Endothelial Growth Factor A (antagonists & inhibitors, metabolism)

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