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Assessment of dynamic image analysis as a surrogate dissolution test for a coated multiparticulate product.

Abstract
Dynamic image analysis (DIA) was used to measure particle diameter (D50) of in-process samples removed during fluid bed coating. A single, rapid measurement gave D50 to within 4 mum. Samples removed at intervals of 2% weight gain were readily distinguishable by DIA and by their drug release profiles. Drug release was related to D50. DIA was assessed as a surrogate dissolution test with considerable potential. Current limitations of the approach were presented.
AuthorsGrant Heinicke, Joseph B Schwartz
JournalPharmaceutical development and technology (Pharm Dev Technol) Vol. 11 Issue 4 Pg. 403-8 ( 2006) ISSN: 1083-7450 [Print] England
PMID17101510 (Publication Type: Evaluation Study, Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Coated Materials, Biocompatible
Topics
  • Coated Materials, Biocompatible (analysis)
  • Image Processing, Computer-Assisted (methods)
  • Particle Size
  • Pharmacokinetics

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