Abstract |
Dynamic image analysis ( DIA) was used to measure particle diameter (D50) of in-process samples removed during fluid bed coating. A single, rapid measurement gave D50 to within 4 mum. Samples removed at intervals of 2% weight gain were readily distinguishable by DIA and by their drug release profiles. Drug release was related to D50. DIA was assessed as a surrogate dissolution test with considerable potential. Current limitations of the approach were presented.
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Authors | Grant Heinicke, Joseph B Schwartz |
Journal | Pharmaceutical development and technology
(Pharm Dev Technol)
Vol. 11
Issue 4
Pg. 403-8
( 2006)
ISSN: 1083-7450 [Print] England |
PMID | 17101510
(Publication Type: Evaluation Study, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Coated Materials, Biocompatible
|
Topics |
- Coated Materials, Biocompatible
(analysis)
- Image Processing, Computer-Assisted
(methods)
- Particle Size
- Pharmacokinetics
|