Functional alterations in NO, PGI2 and EDHF pathways in the aortic endothelium after myocardial infarction in rats.

Abstract

BACKGROUND:

Previous work on endothelial dysfunction in post-MI heart failure has shown conflicting results.

AIM:

To analyze gender related alterations in NO-, PGI(2)- and EDHF-dependent endothelial function in the thoracic aorta 7 and 42 days after myocardial infarction (MI).

METHODS AND RESULTS:

MI was induced by coronary artery ligation in female and male Sprague-Dawley rats. There was no gender related difference in infarct-size or in the impairment of fractional shortening of the left ventricle 42 days after coronary ligation. Neither acetylcholine-induced (Ach) vasodilation nor basal PGI(2) production in the aorta was modified by coronary ligation. Interestingly, 7 days after MI, basal NO production was impaired and the EDHF component of Ach-induced vasodilation was up-regulated, in both male and female rats. However, 42 days post-MI, basal NO was only impaired in male rats, while EDHF was only up-regulated in female rats.

CONCLUSION:

MI induced impairment of functional activity of basal NO production and adaptive up-regulation of the EDHF component of Ach-induced relaxation. The above alterations in endothelial function in the aorta were gender-specific at 42 days but not 7 days after MI. Some of the previously reported discrepancies in the development of endothelial dysfunction in the post-MI period may be gender related differences.

• Authors: Gabor Csanyi, Michael Bauer, Wolfgang Dietl, Magdalena Lomnicka, Tatiana Stepuro, Bruno K Podesser, Stefan Chlopicki
• Journal: European journal of heart failure (Eur J Heart Fail) Vol. 8 Issue 8 Pg. 769-76 (Dec 2006) ISSN: 1388-9842 [Print] England
• PMID: 17101291 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Biological Factors
• Potassium Channels
• endothelium-dependent hyperpolarization factor
• Nitric Oxide
• Cytochrome P-450 Enzyme System
• Epoprostenol
• Prostaglandin-Endoperoxide Synthases

Topics

• Animals
• Aorta (metabolism)
• Biological Factors (metabolism)
• Cytochrome P-450 Enzyme System (metabolism)
• Endothelium (metabolism)
• Epoprostenol (metabolism)
• Female
• Male
• Myocardial Infarction (metabolism, physiopathology, surgery)
• Nitric Oxide (metabolism)
• Potassium Channels (metabolism)
• Prostaglandin-Endoperoxide Synthases (metabolism)
• Rats
• Rats, Sprague-Dawley
• Up-Regulation
• Ventricular Remodeling