[Specific features of the pathogenesis of epichlorohydrin eye burns and their treatment (an experimental clinico-morphological study)].

Abstract

Specific features in the pathogenesis of ocular burns with a solution of an organic product, epichlorohydrin, are analyzed. Abnormalities in the vascular system anterior portion were revealed, related to the toxic effect of the agent on tissue vessels and to enhanced permeability and involvement of not only the cornea, but (and even more so) of the iris, where necrotic changes and hemorrhages eventuating in iris atrophy were detectable. Contrykal (hordox) therapy promoted a drastic inhibition of leukocytic and lymphocytic migration into burnt tissue, this resulting in a month in the formation of gentle cicatricial tissue with negligible residual inflammatory infiltration in the burn wound. Iris changes still persisted, since the drug appeared to have no effect on this process.

• Authors: I P Khoroshilova, L V Ilatovskaia, G G Bordiugova, F S Gakhramanov
• Journal: Vestnik oftalmologii (Vestn Oftalmol) 1991 Jan-Feb Vol. 107 Issue 1 Pg. 12-6 ISSN: 0042-465X [Print] Russia (Federation)
• Vernacular Title: Osobennosti patogeneza ozhogov glaz épikhlorgidrinom i ikh lechenie (éksperimental'noe kliniko-morfologicheskoe issledovanie).
• PMID: 1709763 (Publication Type: English Abstract, Journal Article)

Chemical References

• Epichlorohydrin
• Aprotinin

Topics

• Animals
• Aprotinin (therapeutic use)
• Atrophy
• Burns, Chemical (drug therapy, etiology, pathology)
• Cornea (pathology)
• Epichlorohydrin (toxicity)
• Eye Burns (chemically induced, drug therapy, pathology)
• Iris (pathology)
• Necrosis
• Rabbits