Abstract | OBJECTIVES: The development of intra-abdominal tumor spread and port-site metastases in urothelial cancer are still questions regarding the safety of laparoscopic methods for the resection of malignancies. Currently, the actual incidence of intra-abdominal tumor spread and port-site metastasis remains unknown. Herein, we investigated the influence of antiadhesive oligopeptides and cytotoxic agents (administered intraperitoneally) on implantation of a tumor cell suspension after laparoscopic surgery in an experimental model. METHODS: Forty C57 bl6 mice underwent laparoscopy with CO(2) insufflation and instillation of a MB 49 syngenic urothelial tumor cell suspension into the abdominal cavity. Mice were randomly allocated to one of the following groups (n=10 mice per group), and all agents were administrated intraperitoneally: (1) control ( phosphate-buffered saline); (2) unspecific oligopeptides; (3) specific oligopeptides; (4) mitomycin. The mice were sacrificed 14 d after the procedure, and the peritoneal cavity and port sites examined for the presence of tumor. RESULTS: CONCLUSIONS:
|
Authors | Andreas Jurczok, Astrid Schneider, Paolo Fornara |
Journal | European urology
(Eur Urol)
Vol. 52
Issue 2
Pg. 590-5
(Aug 2007)
ISSN: 0302-2838 [Print] Switzerland |
PMID | 17097215
(Publication Type: Journal Article)
|
Chemical References |
|
Topics |
- Analysis of Variance
- Animals
- Chi-Square Distribution
- Female
- Injections, Intraperitoneal
- Laparoscopy
(adverse effects)
- Mice
- Mice, Inbred C57BL
- Mitomycin
(administration & dosage, pharmacology)
- Models, Animal
- Neoplasm Metastasis
(prevention & control)
- Neoplasm Seeding
- Neoplasm Transplantation
- Oligopeptides
(administration & dosage, pharmacology)
- Random Allocation
- Tumor Cells, Cultured
|