Abstract |
A 42-year-old woman was referred to us for the treatment of relapsed Philadelphia-positive acute lymphoblastic leukemia (Ph+ALL), which had been maintained in complete remission for seven years after an allogeneic bone marrow transplantation (allo-BMT) from an unrelated donor. She received remission-reinduction chemotherapy combined with imatinib mesylate. After the documentation of the molecular remission of Ph+ALL, she underwent the second allo-BMT from another unrelated donor. GVHD prophylaxis consisted of tacrolimus (TAC) and short-term methotrexate. On day 21, she suddenly suffered from an intermittent severe, cramp-like pain in the right lower limb. The typical pain profile and exclusion of other causative diseases suggested calcineurin-inhibitor induced pain syndrome (CIPS) as a possible cause of pain. The pain was gradually relieved after discontinuation of TAC and administration of several analgesic drugs. CIPS is rarely seen following allogeneic stem cell transplantation (allo-SCT); only three cases have been so far reported to our knowledge. Thus, physicians should be alert to this complication in patients receiving allo-SCT.
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Authors | Shuichiro Takashima, Akihiko Numata, Toshihiro Miyamoto, Tsuyoshi Shirakawa, Rieko Kinoshita, Kouji Kato, Katsuto Takenaka, Naoki Harada, Koji Nagafuji, Shuichi Taniguchi, Mine Harada |
Journal | [Rinsho ketsueki] The Japanese journal of clinical hematology
(Rinsho Ketsueki)
Vol. 47
Issue 10
Pg. 1372-6
(Oct 2006)
ISSN: 0485-1439 [Print] Japan |
PMID | 17094576
(Publication Type: Case Reports, English Abstract, Journal Article)
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Chemical References |
- Calcineurin Inhibitors
- Calcineurin
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Topics |
- Adult
- Bone Marrow Transplantation
- Calcineurin
(adverse effects)
- Calcineurin Inhibitors
- Complex Regional Pain Syndromes
(chemically induced)
- Female
- Hematopoietic Stem Cell Transplantation
- Humans
- Precursor Cell Lymphoblastic Leukemia-Lymphoma
(therapy)
- Transplantation Conditioning
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