Protective effect of cloricromene, a coumarine derivative, in hypovolemic hemorrhagic shock in the rat.

Abstract

Hypovolemic hemorrhagic shock was induced in male anesthetized rats by intermittently withdrawing blood from an iliac catheter over a period of 20 min until mean arterial pressure (MAP) fell to 30 mm Hg. Survival rate, MAP, plasma myocardial depressant factor (MDF) activity and plasma levels of both TxB2 and 6-keto PGF1 alpha were then evaluated. Cloricromene (0.5, 1, and 2 mg/kg) or an equal volume of vehicle (0.9% NaCl solution) were injected intravenously 5 min after the end of the bleeding. Hemorrhagic shocked rats showed enhanced plasma levels of MDF, TxB2 and 6-keto PGF1 alpha. All vehicle-treated rats died within 25 min. Cloricromene (1 and 2 mg/kg) given curatively significantly increased survival rate and blunted the rise in plasma MDF and TxB2. Moreover, cloricromene reversed the severe hypotension and the ST-segment elevation occurring during hemorrhagic shock. The data suggest that cloricromene exerts beneficial effects in experimental hypovolemic shock, probably reversing myocardial failure.

• Authors: R Sturniolo, F Squadrito, G M Campo, R Vinci, A Calatroni, M Prosdocimi, A P Caputi
• Journal: Journal of cardiovascular pharmacology (J Cardiovasc Pharmacol) Vol. 17 Issue 2 Pg. 261-6 (Feb 1991) ISSN: 0160-2446 [Print] United States
• PMID: 1709231 (Publication Type: Journal Article)

Chemical References

• Myocardial Depressant Factor
• Thromboxane B2
• 6-Ketoprostaglandin F1 alpha
• cloricromen
• Chromonar

Topics

• 6-Ketoprostaglandin F1 alpha (blood)
• Animals
• Blood Pressure (drug effects)
• Chromonar (analogs & derivatives, pharmacology)
• Electrocardiography (drug effects)
• Male
• Myocardial Depressant Factor (blood)
• Rats
• Rats, Inbred Strains
• Shock, Hemorrhagic (blood, drug therapy, mortality)
• Thromboxane B2 (blood)