HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Human breast cancer cell lines and tissues express tartrate-resistant acid phosphatase (TRAP).

Abstract
Tartrate-resistant acid phosphatase (TRAP) is expressed by osteoclasts, macrophages and dendritic cells. TRAP has been identified in a wide variety of tissues, however, its biological function is not fully understood. Serum TRAP is a marker of diseases involving excessive bone resorption including metastatic bone disease in breast cancer patients and can be used to monitor responses to treatment. Our aim in this study was to determine whether TRAP is expressed by human breast tumours. Four breast cancer cell lines were assayed for TRAP activity. MDA-MB-435, the most tumourigenic line, had an activity twofold higher than the other cell lines. Immunohistochemistry using a TRAP specific antibody confirmed that both cell lines and human breast tumours express TRAP. Expression was absent in benign tissues and abundant in more aggressive tumours. This work suggests that tumour derived TRAP contributes to the raised enzyme activity found in the serum of breast cancer patients.
AuthorsLisa M Adams, Michael J Warburton, Alison R Hayman
JournalCell biology international (Cell Biol Int) Vol. 31 Issue 2 Pg. 191-5 (Feb 2007) ISSN: 1065-6995 [Print] England
PMID17088078 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Isoenzymes
  • Acid Phosphatase
  • Tartrate-Resistant Acid Phosphatase
Topics
  • Acid Phosphatase (metabolism)
  • Breast Neoplasms (enzymology, pathology)
  • Cell Line, Tumor
  • Female
  • Humans
  • Immunohistochemistry
  • Isoenzymes (metabolism)
  • Tartrate-Resistant Acid Phosphatase

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: