Abstract | BACKGROUND: MATERIALS AND METHODS: Female C57BL/6 mice were either inoculated with 10(8) H. pylori, Helicobacter felis or water. In the nonpregnant study, 15 mice from each group were sacrificed after 4 and 20 weeks of infection. In the pregnancy study, after 6 weeks of infection all female mice were mated and approximately 2 weeks after mating, half of the pregnant mice (n = 9/group) from each group were sacrificed. The remaining mice were allowed to give birth, and approximately 4 weeks after birth, mice were asphyxiated with CO2, followed by heart puncture, and killed by cervical dislocation. Serum ferritin and iron were determined with a micro-particle enzyme immunoassay method and by a timed-endpoint method. RESULTS: Serum iron levels in mice infected with H. felis were significantly (p < .05) lowered compared to control (24%) and H. pylori (27%)-infected mice at 4 weeks of infection. Serum iron in the control, H. pylori and H. felis groups were significantly (p < .05) elevated at 20 weeks by 39, 26 and 77%, respectively, compared to 4 weeks of infection. H. felis-infected mice had a significantly (p < .05) decreased serum ferritin level during pregnancy (61%) compared to H. pylori-infected mice. CONCLUSION: These results suggest that H. felis but not H. pylori infection causes an acute iron deficiency in normal and pregnant mice.
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Authors | Rikke Gøbel, Erin L Symonds, Stawatiki Kritas, Ross N Butler, Coung Duy Tran |
Journal | Helicobacter
(Helicobacter)
Vol. 11
Issue 6
Pg. 529-32
(Dec 2006)
ISSN: 1083-4389 [Print] England |
PMID | 17083374
(Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
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Topics |
- Animals
- Female
- Ferritins
(blood)
- Helicobacter Infections
(blood, complications, metabolism)
- Helicobacter felis
- Iron
(blood, metabolism)
- Iron Deficiencies
- Mice
- Mice, Inbred C57BL
- Pregnancy
- Pregnancy Complications, Infectious
(blood, etiology, metabolism)
- Time Factors
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