[DNA ploidy and results of first line chemotherapy in ovarian cancer patients].

Abstract

AIM OF THE STUDY:

The prognostic significance of DNA ploidy in ovarian cancer patients determined by flow cytometric analysis, in correlation with effectiveness of first line chemotherapy.

MATERIAL AND METHODS:

DNA ploidy by FC was investigated in group of 102 ovarian cancer patients from fresh frozen samples (4 patients was excluded from the study).

RESULTS:

Positive answer for first line treatment we notified in 64(62,75%) cases, lack of answer 34 (37,25%) patients. Aneuploidy was more frequent in negative group 31(91,18%), diploid tumours occurred in 3(8.82%) cases. In positive group aneuploid tumours occurred in 29(45,31%) and diploid in 35(54,69%) patients (p<0,001). Median survival in positive group--45 months, in negative group 12 months (p<0,0001). In positive group median survival in patients with aneuploid tumours--31 months, in patients with diploid tumours median survival was not reached (p=0,0102). In negative group DNA ploidy has no impact on survival (p=0,1027)

CONCLUSIONS:

1. DNA ploidy determined by flow cytometry is prognostic factor in ovarian cancer patients who answered positively for first line treatment. 2. Aneuploid tumours appear much often then diploid in group of patient who did not answer for first line chemotherapy 3. Patients with diploid tumours have better prognosis. 4. Lack of positive answer for first line treatment is bad prognostic factor.

• Authors: Tomasz Milczek, Dagmara Klasa-Mazurkiewicz, Janusz Emerich, Jarosław Debniak
• Journal: Ginekologia polska (Ginekol Pol) Vol. 77 Issue 8 Pg. 589-96 (Aug 2006) ISSN: 0017-0011 [Print] Poland
• Vernacular Title: Wpływ ploidii DNA na rokowanie w zalezności od odpowiedzi na chemioterapie i rzutu u chorych na raka jajnika.
• PMID: 17076189 (Publication Type: English Abstract, Journal Article)

Chemical References

• Antineoplastic Agents
• DNA, Neoplasm

Topics

• Adult
• Aneuploidy
• Antineoplastic Agents (therapeutic use)
• DNA, Neoplasm (analysis, genetics)
• Diploidy
• Disease-Free Survival
• Female
• Flow Cytometry
• Gene Expression Regulation, Neoplastic (genetics)
• Humans
• Middle Aged
• Multivariate Analysis
• Neoplasm Staging
• Ovarian Neoplasms (drug therapy, genetics, pathology)
• Ploidies
• Poland
• Prognosis
• Retrospective Studies