Successful treatment of Candida krusei fungemia with amphotericin B and caspofungin.

Abstract

We report a leukemic patient with C. krusei fungemia who failed to respond to liposomal amphotericin B therapy alone. The addition of caspofungin eradicated infection and was well tolerated. Our report is the first to describe successful treatment of a patient with invasive C. krusei infection using this combination of antifungals. Combination therapy could be a useful treatment option for invasive candidosis, particularly when caused by more resistant species such as C. krusei.

• Authors: W J Olver, F Scott, G S Shankland
• Journal: Medical mycology (Med Mycol) Vol. 44 Issue 7 Pg. 655-7 (Nov 2006) ISSN: 1369-3786 [Print] England
• PMID: 17071561 (Publication Type: Case Reports, Journal Article)

Chemical References

• Echinocandins
• Lipopeptides
• Peptides, Cyclic
• Amphotericin B
• Caspofungin

Topics

• Adult
• Amphotericin B (pharmacology, therapeutic use)
• Candida (drug effects, isolation & purification)
• Candidiasis (drug therapy, microbiology)
• Caspofungin
• Drug Therapy, Combination
• Echinocandins
• Fungemia (drug therapy)
• Humans
• Leukemia (complications, drug therapy)
• Lipopeptides
• Male
• Peptides, Cyclic (pharmacology, therapeutic use)
• Treatment Outcome