Renal ultrasound studies after endoscopic injection of dextranomer/hyaluronic acid copolymer for vesicoureteral reflux.

Abstract

OBJECTIVES:

To examine the outcomes of renal ultrasound studies after subureteral injection of dextranomer/hyaluronic acid copolymer and provide recommendations for postoperative management of vesicoureteral reflux (VUR).

METHODS:

Pediatric patients aged 15 years or younger with uncomplicated primary VUR were recruited for endoscopic treatment with dextranomer/hyaluronic acid gel. After undergoing the procedure, patients were instructed to continue prophylactic antibiotic treatment until a follow-up voiding cystourethrogram was obtained 2 weeks or more after treatment. VUR resolution was defined as grade 0. Repeat endoscopic injection was offered to patients with persistent VUR. Postoperative renal ultrasound scans were obtained on the same day as the voiding cystourethrogram.

RESULTS:

Of 120 patients treated, 6 were lost to follow-up and 14 had not yet undergone the posttreatment evaluation. The 100 remaining patients (efficacy population) had a mean age of 4.2 years (range 0.5 to 15), and the median reflux grade was 2 (range 1 to 5). The overall VUR resolution rate for the patients was 87% after endoscopic injection. Of 100 patients, 88 achieved complete resolution after a single injection and 19 required a repeat injection. Of the 100 patients who underwent postoperative ultrasound examination, none demonstrated renal ultrasound changes consistent with significant ureteral obstruction or renal parenchymal changes.

CONCLUSIONS:

Renal ultrasound studies after endoscopic treatment with dextranomer/hyaluronic acid gel are unnecessary after determination of reflux resolution by voiding cystourethrography.

• Authors: Richard N Yu, Eric A Jones, David R Roth
• Journal: Urology (Urology) Vol. 68 Issue 4 Pg. 866-8; discussion 868-9 (Oct 2006) ISSN: 1527-9995 [Electronic] United States
• PMID: 17070369 (Publication Type: Journal Article)

Chemical References

• Dextrans
• Gels
• dextranomer-hyaluronic acid copolymer
• Hyaluronic Acid

Topics

• Child, Preschool
• Dextrans (administration & dosage)
• Endoscopy
• Gels (administration & dosage)
• Humans
• Hyaluronic Acid (administration & dosage)
• Injections (methods)
• Microspheres
• Treatment Outcome
• Ultrasonography
• Vesico-Ureteral Reflux (diagnostic imaging, therapy)