Abstract |
Recurrent immune thrombocytopenic purpura ( ITP) is defined as the recurrence of ITP after at least 3 months of remission sustained without treatment. Among 340 children with ITP, 14 had recurrent ITP (4.1%). Ten were females. The initial course was acute in 8 patients and chronic in 6. The median time to recurrence was 33 months (range 4-120). Only 1 patient had a second recurrence. Twelve (86%) achieved complete (n = 10) or partial (n = 2) remission, two of them after splenectomy. One patient continued to require treatment at 10 months from recurrence. One child died of intracranial hemorrhage despite aggressive treatment including splenectomy and craniotomy.
|
Authors | Somasundaram Jayabose, Oya Levendoglu-Tugal, Mehmet F Ozkaynak, Claudio Sandoval |
Journal | Pediatric hematology and oncology
(Pediatr Hematol Oncol)
Vol. 23
Issue 8
Pg. 677-82
(Dec 2006)
ISSN: 1521-0669 [Electronic] England |
PMID | 17065144
(Publication Type: Journal Article)
|
Chemical References |
- Immunoglobulins, Intravenous
- Immunosuppressive Agents
- Prednisone
- Methylprednisolone
|
Topics |
- Adolescent
- Adult
- Cerebral Hemorrhage
(etiology)
- Child
- Child, Preschool
- Combined Modality Therapy
- Female
- Follow-Up Studies
- Humans
- Immunoglobulins, Intravenous
(therapeutic use)
- Immunosuppressive Agents
(therapeutic use)
- Infant
- Lupus Erythematosus, Systemic
(complications)
- Male
- Methylprednisolone
(therapeutic use)
- Platelet Count
- Prednisone
(therapeutic use)
- Purpura, Thrombocytopenic, Idiopathic
(complications, epidemiology, surgery, therapy)
- Recurrence
- Remission Induction
- Splenectomy
|