Abstract | BACKGROUND: METHODS AND RESULTS: A prospective randomized study was conducted with 150 patients who underwent scheduled coronary artery bypass grafting to compare a group of patients receiving 0.02 microg x kg(-1) x min(-1) of hANP from the initiation of CPB with a group not receiving hANP. Hemodynamics, levels of atrial and brain natriuretic peptides (BNP), angiotensin-II and aldosterone, renin activity, and left ventricular (LV) function were examined. The hANP group showed significantly lower renin activity and lower levels of angiotensin-II and aldosterone during the early postoperative period, compared with the non-hANP group. The incidence of postoperative ventricular arrhythmia and the postoperative peak level of creatine kinase-MB were significantly lower in the hANP group. BNP at 1 month after surgery and measures of LV function were also significantly lower in the hANP group. CONCLUSIONS: Low-dose continuous infusion of hANP during cardiac surgery not only had a compensatory effect for the imperfections of CPB during the early postoperative period but also an inhibitory effect on postoperative LV remodeling and a reduction in ischemia/reperfusion injury. hANP should be part of the postoperative care for cardiac surgery.
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Authors | Akira Sezai, Mitsumasa Hata, Shinji Wakui, Motomi Shiono, Nanao Negishi, Yuji Kasamaki, Satoshi Saito, Jitsu Kato, Kazutomo Minami |
Journal | Circulation journal : official journal of the Japanese Circulation Society
(Circ J)
Vol. 70
Issue 11
Pg. 1426-31
(Nov 2006)
ISSN: 1346-9843 [Print] Japan |
PMID | 17062965
(Publication Type: Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Chemical References |
- Natriuretic Peptide, Brain
- Aldosterone
- Atrial Natriuretic Factor
- Creatine Kinase, MB Form
- Renin
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Topics |
- Aged
- Aldosterone
(blood)
- Arrhythmias, Cardiac
(physiopathology)
- Atrial Natriuretic Factor
(administration & dosage, pharmacology, therapeutic use)
- Blood Pressure
(drug effects, physiology)
- Cardiopulmonary Bypass
(methods)
- Coronary Artery Disease
(surgery)
- Creatine Kinase, MB Form
(blood)
- Dose-Response Relationship, Drug
- Female
- Humans
- Infusions, Intravenous
- Male
- Middle Aged
- Natriuretic Peptide, Brain
(blood)
- Postoperative Period
- Renin
(blood)
- Reperfusion Injury
(physiopathology, prevention & control)
- Ventricular Function, Left
(drug effects, physiology)
- Ventricular Remodeling
(drug effects, physiology)
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