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Evolving simplified treatment strategies for HIV infection: the role of a single-class quadruple-nucleoside/nucleotide regimen of trizivir and tenofovir.

Abstract
Simplified antiretroviral regimens have been developed with the aim of improving treatment adherence and quality of life of HIV-infected patients. The single-class triple-nucleoside reverse transcriptase inhibitor combination has contributed to the improvement of the management of HIV infection, especially in patients with adherence problems and special groups of the patient population. Such a regimen remains an alternative option because of lower virological efficacy compared with the preferred multiclass antiretroviral regimens. However, recently, a nucleoside reverse transcriptase inhibitor abacavir/lamivudine/zidovudine plus tenofovir has been investigated in both antiretroviral-naive patients and in heavily pre-treated patients, as well in the setting of simplification/switching strategies. This experimental combination could be a safe and attractive option that offers the advantages of limited toxicity, few drug interactions and the use of future treatment options with new drugs, especially for patients in later stages of infection.
AuthorsClaudio M Mastroianni, Gabriella d'Ettorre, Vincenzo Vullo
JournalExpert opinion on pharmacotherapy (Expert Opin Pharmacother) Vol. 7 Issue 16 Pg. 2233-41 (Nov 2006) ISSN: 1744-7666 [Electronic] England
PMID17059380 (Publication Type: Journal Article, Review)
Chemical References
  • Anti-HIV Agents
  • Dideoxynucleosides
  • Drug Combinations
  • Organophosphonates
  • Reverse Transcriptase Inhibitors
  • abacavir, lamivudine, and zidovudine drug combination
  • Lamivudine
  • Zidovudine
  • Tenofovir
  • Adenine
Topics
  • Adenine (analogs & derivatives, classification, pharmacology, therapeutic use)
  • Anti-HIV Agents (pharmacology, therapeutic use)
  • Dideoxynucleosides (classification, pharmacology, therapeutic use)
  • Drug Combinations
  • HIV Infections (drug therapy, virology)
  • HIV-1 (drug effects)
  • Humans
  • Lamivudine (classification, pharmacology, therapeutic use)
  • Organophosphonates (classification, pharmacology, therapeutic use)
  • Reverse Transcriptase Inhibitors (classification, pharmacology, therapeutic use)
  • Tenofovir
  • Zidovudine (classification, pharmacology, therapeutic use)

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