Abstract | BACKGROUND: There is no effective treatment for progressive macular hypomelanosis. Recent findings indicate that Propionibacterium acnes may play a role in the pathogenesis. OBJECTIVES: We sought to compare the effectiveness of antimicrobial therapy with anti-inflammatory therapy in patients with progressive macular hypomelanosis. METHODS: A total of 45 patients were randomized to a within-patient left-right comparison study of benzoyl peroxide 5% hydrogel/ clindamycin 1% lotion in combination with UVA irradiation versus fluticasone 0.05% cream in combination with UVA irradiation. Repigmentation was determined by photometric measurements of changes in skin color and by patient and dermatologist assessment using before and after photographs. RESULTS:
Benzoyl peroxide 5% hydrogel, clindamycin 1% lotion, and UVA led to better repigmentation than fluticasone 0.05% cream in combination with UVA irradiation in all measurements. (Photometric measurements P = .007, patient assessment P < .0001, and dermatologist assessment P < .0001.) LIMITATIONS: There was difficult objective color measurement. Therefore, subjective assessment has important additional value. Right-left comparisons have certain inherent limitations. CONCLUSION: Antimicrobial therapy in conjunction with light was more effective in repigmentation in patients with progressive macular hypomelanosis than a combination of anti-inflammatory therapy and light.
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Authors | Germaine N Relyveld, Melanie M Kingswijk, Johannes B Reitsma, Henk E Menke, Jan D Bos, Wiete Westerhof |
Journal | Journal of the American Academy of Dermatology
(J Am Acad Dermatol)
Vol. 55
Issue 5
Pg. 836-43
(Nov 2006)
ISSN: 1097-6787 [Electronic] United States |
PMID | 17052490
(Publication Type: Journal Article, Randomized Controlled Trial)
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Chemical References |
- Androstadienes
- Anti-Bacterial Agents
- Anti-Inflammatory Agents
- Hydrogels
- Clindamycin
- Fluticasone
- Benzoyl Peroxide
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Topics |
- Administration, Topical
- Adult
- Androstadienes
(adverse effects, therapeutic use)
- Anti-Bacterial Agents
(administration & dosage, adverse effects, therapeutic use)
- Anti-Inflammatory Agents
(adverse effects, therapeutic use)
- Benzoyl Peroxide
(administration & dosage, adverse effects, therapeutic use)
- Clindamycin
(administration & dosage, adverse effects, therapeutic use)
- Disease Progression
- Female
- Fluticasone
- Humans
- Hydrogels
- Hypopigmentation
(drug therapy, pathology, therapy)
- Male
- Treatment Outcome
- Ultraviolet Therapy
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