Abstract | BACKGROUND: Pulmonary function tests (PFTs) and especially spirometry measures are useful tools in evaluating early response to treatment of asthma in children mainly due to their worldwide availability. The aim of our study was to determine the effects of anti-asthma treatment in children, equally on FEV(1), FEF25-75%, R(int) and SR(aw) values. METHODS: Children 6-18 years of age with moderate atopic asthma were randomized to 4-week, placebo-controlled, double-blind trial. Patients were randomly allocated to receive 200 microg budesonide (B) (n=29), 5 or 10 mg (according to age) montelukast (M) (n=29), 200 microg B + 5 or 10 mg M (n=29), 200 microg B + 9 microg formoterol (F) (n=29) or placebo (n=27). FEV(1,) FEF25-75%, R(int), SR(aw) were measured before and after treatment. RESULTS: R(int), SR(aw), FEV(1) improved significantly in all active treatment groups while FEF25-75% improved significantly only in BM group and M group. Combination therapy, showed significantly greater effects on R(int) than monotherapy: BM group compared to B group (P=0.01) and M group (P=0.03) and BF group compared to B group (P=0.01) and M group (P=0.04). CONCLUSION: This study shows that using single parameter for monitoring asthma can be misleading. Using combination of lung function techniques provides better assessment of treatment. Results of our study confirm this hypothesis. The best effect on large and small airways was achieved with combined anti-inflammatory therapy.
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Authors | Iwona Stelmach, Tomasz Grzelewski, Monika Bobrowska-Korzeniowska, Piotr Stelmach, Piotr Kuna |
Journal | Pulmonary pharmacology & therapeutics
(Pulm Pharmacol Ther)
Vol. 20
Issue 6
Pg. 691-700
( 2007)
ISSN: 1094-5539 [Print] England |
PMID | 17046300
(Publication Type: Comparative Study, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Chemical References |
- Acetates
- Anti-Asthmatic Agents
- Bronchodilator Agents
- Cyclopropanes
- Ethanolamines
- Quinolines
- Sulfides
- Budesonide
- montelukast
- Formoterol Fumarate
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Topics |
- Acetates
(therapeutic use)
- Adolescent
- Airway Resistance
(drug effects)
- Anti-Asthmatic Agents
(therapeutic use)
- Asthma
(drug therapy)
- Bronchodilator Agents
(therapeutic use)
- Budesonide
(therapeutic use)
- Child
- Cyclopropanes
- Double-Blind Method
- Drug Therapy, Combination
- Ethanolamines
(therapeutic use)
- Female
- Forced Expiratory Volume
(drug effects)
- Formoterol Fumarate
- Humans
- Male
- Maximal Midexpiratory Flow Rate
(drug effects)
- Plethysmography, Whole Body
- Quinolines
(therapeutic use)
- Respiratory Function Tests
(methods)
- Sulfides
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