[Beta 2-microglobulin in the diagnosis of specific involvement of the kidneys in acute leukemias].

Abstract

Measurements of the serum and urinary beta 2-microglobulin (beta 2-Mg) concentrations in 138 adult patients with various forms of acute leukemia, which were carried out in various periods of the disease, have revealed that serum beta 2-Mg levels were two times higher in the patients with leukemic involvement of the kidneys (5.54 +/- 3.50 mg/l) than in those without renal involvement (2.77 +/- 1.07 mg/l). Consequently, urinary beta 2-Mg excretion was much higher in the patients with renal involvement than in those with intact kidneys (1.512 +/- 3.222 mg/l vs. 0.388 +/- 1.175 mg/l). Mathematical analysis has shown that the risk of leukemic involvement of the kidneys makes up 93.3 percent in acute leukemia patients with serum beta 2-Mg levels surpassing 6.0 mg/l. This permitted a conclusion on the diagnostic value of beta 2-Mg measurements for the detection of specific involvement of the kidneys in acute leukemia.

• Authors: V G Vorob'ev, E M Trunova, N N Borovkov
• Journal: Laboratornoe delo (Lab Delo) Issue 10 Pg. 31-4 ( 1990) ISSN: 0023-6748 [Print] Russia (Federation)
• Vernacular Title: Beta 2-mikroglobulin v diagnostike spetsificheskogo porazheniia pochek pri ostrykh leĭkozakh.
• PMID: 1704452 (Publication Type: English Abstract, Journal Article)

Chemical References

• beta 2-Microglobulin

Topics

• Acute Disease
• Adolescent
• Adult
• Aged
• Female
• Humans
• Kidney Neoplasms (blood, pathology, urine)
• Leukemia (blood, pathology, urine)
• Male
• Middle Aged
• beta 2-Microglobulin (analysis, urine)