Beneficial effect of polymyxin B-immobilized fiber column (PMX) hemoperfusion treatment on acute exacerbation of idiopathic pulmonary fibrosis.

Abstract

OBJECTIVE:

This study was aimed to investigate the effect of polymyxin B-immobilized fiber column (PMX) hemoperfusion treatment on the acute exacerbation of idiopathic pulmonary fibrosis (IPF).

PATIENTS AND METHODS:

Six patients with a clinical diagnosis of idiopathic pulmonary fibrosis (IPF) who developed acute exacerbation were included in this study. Although five of six patients were treated with high-dose corticosteroid therapy, mechanical ventilation was necessary for all six patients due to severe respiratory failure. Blood endotoxin levels were undetectable in all patients. PMX treatment was performed on these six patients.

RESULTS:

In four of six patients, alveolar-arterial difference of oxygen (AaDO(2)), serum KL-6 and lactate dehydrogenase (LDH) were improved after PMX treatment. These four patients were successfully weaned from mechanical ventilation and survived more than 30 days after the initial PMX treatment.

CONCLUSION:

These data suggest a potential beneficial effect of PMX treatment on acute exacerbation of IPF.

• Authors: Yoshitsugu Seo, Shinji Abe, Misuzu Kurahara, Daisuke Okada, Yoshinobu Saito, Jiro Usuki, Arata Azuma, Kiyoshi Koizumi, Shoji Kudoh
• Journal: Internal medicine (Tokyo, Japan) (Intern Med) Vol. 45 Issue 18 Pg. 1033-8 ( 2006) ISSN: 1349-7235 [Electronic] Japan
• PMID: 17043373 (Publication Type: Journal Article)

Chemical References

• Antigens, Neoplasm
• Glucocorticoids
• MUC1 protein, human
• Mucin-1
• Mucins
• L-Lactate Dehydrogenase
• Polymyxin B
• Oxygen

Topics

• Acute Disease
• Aged
• Antigens, Neoplasm (blood)
• Female
• Glucocorticoids (therapeutic use)
• Hemoperfusion (methods)
• Humans
• L-Lactate Dehydrogenase (blood)
• Male
• Middle Aged
• Mucin-1
• Mucins (blood)
• Oxygen (analysis)
• Pilot Projects
• Polymyxin B (administration & dosage)
• Pulmonary Fibrosis (drug therapy, therapy)
• Respiration, Artificial
• Survival Analysis
• Treatment Outcome