Abstract |
Anthracyclines are effective in the treatment of leukemia, but their use is limited because of cardiotoxicity. Liposomal daunorubicin (L-DNR) is potentially less cardiotoxic than daunorubicin (DNR). We compared in vitro cytotoxicity in pediatric acute leukemia samples and found no significant differences between cytotoxicity of DNR and L-DNR.
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Authors | Bianca F Goemans, Christian M Zwaan, Dirk Reinhardt, Brenda E S Gibson, K Hählen, Gert Jan L Kaspers |
Journal | Haematologica
(Haematologica)
Vol. 91
Issue 11
Pg. 1573-4
(Nov 2006)
ISSN: 1592-8721 [Electronic] Italy |
PMID | 17043024
(Publication Type: Comparative Study, Letter)
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Chemical References |
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Topics |
- Adolescent
- Child
- Child, Preschool
- Daunorubicin
(administration & dosage, adverse effects)
- Female
- Humans
- Leukemia, Myeloid, Acute
(drug therapy, pathology)
- Liposomes
(administration & dosage)
- Male
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