Intrathecal donor lymphocyte infusion for the treatment of suspected refractory lymphomatous meningitis: a case report.

Abstract

A 43-year-old female with large T-cell non-Hodgkin's lymphoma and central nervous system (CNS) involvement underwent HLA-identical-sibling peripheral blood stem cell transplantation (SCT) during her third complete remission. She presented a possible refractory CNS relapse 5 months after the transplant. She was then treated with intrathecal (IT) donor lymphocyte infusions (DLI). No side effects were observed after three DLI injections. The patient died 13 months later from infectious complications with no evidence of progressive disease. To our knowledge, this is the first case report of IT DLI for possible refractory lymphomatous meningitis.

• Authors: N Meuleman, I Ahmad, H Duvillier, M Lemort, J Bennani, M Martiat, L Lagneaux, D Bron
• Journal: European journal of haematology (Eur J Haematol) Vol. 77 Issue 6 Pg. 523-6 (Dec 2006) ISSN: 0902-4441 [Print] England
• PMID: 17042768 (Publication Type: Case Reports, Journal Article)

Chemical References

• HLA Antigens
• Interleukin-6
• Interleukin-8

Topics

• Adult
• Disease Progression
• Female
• HLA Antigens
• Humans
• Injections, Spinal
• Interleukin-6 (biosynthesis)
• Interleukin-8 (biosynthesis)
• Lymphocyte Transfusion
• Lymphoma, Large B-Cell, Diffuse (pathology, therapy)
• Lymphoma, Non-Hodgkin (pathology, therapy)
• Magnetic Resonance Imaging
• Meningitis (complications, pathology, therapy)
• Remission Induction
• Stem Cell Transplantation