Abstract | OBJECTIVE: STUDY DESIGN AND PATIENTS: RESULTS: Prevalences of positive antibody tests to calsequestrin (75.0%) and collagen XIII (43.8%) were significantly greater in Graves' disease (GD) patients with ophthalmopathy than in healthy subjects, whereas modest significance was demonstrated with antibodies against Fp, but not G2s. Significantly greater serum levels of antibodies against calsequestrin, G2s, and collagen XIII, but not Fp, were found in GD patients with ophthalmopathy compared to control patients without eye disease and healthy subjects. CONCLUSIONS:
Calsequestrin and collagen XIII antibodies are the most specific to TAO, whereas antibodies against G2s, and to a lesser extent Fp, are also markers of ophthalmopathy, but less reliable. These results are unique in that it is the first time the significance of a panel of three candidate eye muscle antibodies and a connective tissue antibody have been evaluated in the same patients with ophthalmopathy.
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Authors | Bamini Gopinath, Reilly Musselman, Cherie-Lee Adams, Junichi Tani, Nicole Beard, Jack R Wall |
Journal | Thyroid : official journal of the American Thyroid Association
(Thyroid)
Vol. 16
Issue 10
Pg. 967-74
(Oct 2006)
ISSN: 1557-9077 [Electronic] United States |
PMID | 17042681
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Autoantibodies
- Calsequestrin
- Cell Cycle Proteins
- Flavoproteins
- G2A receptor
- Receptors, G-Protein-Coupled
- Collagen
- Thyroxine
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Topics |
- Adult
- Aged
- Aged, 80 and over
- Autoantibodies
(blood)
- Calsequestrin
(immunology)
- Cell Cycle Proteins
(immunology)
- Collagen
(immunology)
- Enzyme-Linked Immunosorbent Assay
- Female
- Flavoproteins
(immunology)
- Graves Disease
(blood, drug therapy, immunology)
- Graves Ophthalmopathy
(blood, drug therapy, immunology)
- Humans
- Male
- Middle Aged
- Oculomotor Muscles
(immunology)
- Receptors, G-Protein-Coupled
(immunology)
- Reference Values
- Thyroxine
(therapeutic use)
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