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Group B streptococcal pilus proteins contribute to adherence to and invasion of brain microvascular endothelial cells.

Abstract
Surface filamentous structures known as pili have been discovered recently in the gram-positive streptococcal pathogens that cause invasive disease in humans, including group B Streptococcus (GBS). We show that two GBS proteins involved in pilus formation, encoded by pilA and pilB, also facilitate the interaction of this important agent of central nervous system infection with endothelial cells of the human blood-brain barrier.
AuthorsHeather C Maisey, Mary Hensler, Victor Nizet, Kelly S Doran
JournalJournal of bacteriology (J Bacteriol) Vol. 189 Issue 4 Pg. 1464-7 (Feb 2007) ISSN: 0021-9193 [Print] United States
PMID17041051 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, Non-P.H.S.)
Chemical References
  • Bacterial Proteins
  • Fimbriae Proteins
  • Oxidoreductases
  • pilB protein, Bacteria
Topics
  • Bacterial Adhesion (physiology)
  • Bacterial Proteins (biosynthesis, genetics)
  • Brain (blood supply)
  • Cells, Cultured
  • Endothelial Cells (microbiology)
  • Fimbriae Proteins (biosynthesis, genetics)
  • Fimbriae, Bacterial (metabolism)
  • Gene Expression Regulation, Bacterial
  • Humans
  • Oxidoreductases (biosynthesis, genetics)
  • Streptococcus agalactiae (metabolism)

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