Abstract | AIM: METHODS: Circulating immune complexes (CIC) were estimated using 37.5% Polyethylene Glycol 6000(PEG) serum precipitation. Serum estimation of copper (Cu), Iron (Fe) and selenium (Se) was done using the Oxalyl Dihydrazide method, Colorimetric Dipyridyl method and the Differential Pulse Cathodic Stripping Voltametry respectively. RESULTS: The data analysis revealed increased circulating immune complex levels in the precancer and cancer patients. Serum copper levels showed gradual increase from precancer to cancer patients. However, serum iron levels were decreased significantly in the cancer group. Selenium levels showed marked decrease in the cancer group. Among CIC, serum, copper, iron and selenium the best predictors for the occurrence of lesions were age, serum iron, CIC, serum selenium in the decreasing order. CONCLUSION: The present study shows that these immunological and biological markers may be associated with the pathogenesis of oral premalignant and malignant lesions and their progressions. Concerted efforts would, therefore, help in early detection, management, and monitoring the efficacy of treatment.
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Authors | Sunali S Khanna, Freny R Karjodkar |
Journal | Head & face medicine
(Head Face Med)
Vol. 2
Pg. 33
(Oct 16 2006)
ISSN: 1746-160X [Print] England |
PMID | 17040577
(Publication Type: Comparative Study, Journal Article, Multicenter Study, Randomized Controlled Trial)
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Chemical References |
- Antigen-Antibody Complex
- Biomarkers, Tumor
- Trace Elements
- Copper
- Iron
- Selenium
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Topics |
- Adult
- Aged
- Antigen-Antibody Complex
(blood)
- Biomarkers, Tumor
(blood)
- Copper
(blood)
- Female
- Humans
- Iron
(blood)
- Male
- Middle Aged
- Mouth Neoplasms
(blood)
- Precancerous Conditions
(blood)
- Prognosis
- Selenium
(blood)
- Trace Elements
(blood)
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