[Antitumor effects of nobiletin on Heps and its mechanism].

Abstract

AIM:

To study the inhibitory effect and mechanism of nobiletin on Heps tumor bearing mice.

METHODS:

Models of Heps tumor bearing mice were established. The inhibitory rates of tumor growth were calculated, the apoptosis morphology of tumor tissue was observed. The T lymphocyte transformation capacity was tested by MTT assay, the TNFalpha and IL-2 production were measured by LDH kits.

RESULTS:

Nobiletin could significantly inhibit Heps tumor growth. The inhibitory rates were 42.14% - 65.09% (P < 0.01). The morphology of tumor tissues in nobiletin group had typical characters of necrosis and apoptosis through transmission electron microscope. Nobiletin could stimulate T lymphocyte transformation and the production of TNFalpha and IL-2.

CONCLUSION:

Nobiletin has obvious antitumor effect on Heps, the main mechanism is to enhance the cellular immune function and induce apoptosis of tumor tissue.

• Authors: Hong-quan Zhang, Hui Ge, Mei-ying Cheng
• Journal: Yao xue xue bao = Acta pharmaceutica Sinica (Yao Xue Xue Bao) Vol. 41 Issue 8 Pg. 797-800 (Aug 2006) ISSN: 0513-4870 [Print] China
• PMID: 17039791 (Publication Type: English Abstract, Journal Article)

Chemical References

• Antineoplastic Agents, Phytogenic
• Flavones
• Interleukin-2
• Tumor Necrosis Factor-alpha
• nobiletin

Topics

• Animals
• Antineoplastic Agents, Phytogenic (isolation & purification, pharmacology)
• Apoptosis (drug effects)
• Cell Line, Tumor
• Cell Transformation, Neoplastic (drug effects, metabolism, pathology)
• Citrus (chemistry)
• Female
• Flavones (isolation & purification, pharmacology)
• Humans
• Interleukin-2 (biosynthesis)
• Liver Neoplasms, Experimental (pathology, prevention & control, ultrastructure)
• Male
• Mice
• Mice, Inbred ICR
• Plants, Medicinal (chemistry)
• T-Lymphocytes (drug effects, metabolism, pathology)
• Tumor Necrosis Factor-alpha (biosynthesis)