Abstract | BACKGROUND: CASE REPORT: An 18-year-old patient with a 4-year history of NSAID compound analgesic intake presented to the urology department with right-sided flank pain and increased serum creatinine. An obstruction as well as nephrolithiasis were ruled out and the patient was referred to the medical department. Urinalysis showed leukocyturia, mild microhematuria as well as proteinuria of 2.2 g/day whereupon a diagnostic kidney biopsy was performed. Histology revealed a chronic nonpurulent destructive interstitial nephritis. After cessation of analgesic intake, the serum creatinine level fell to the normal range; however, a reduced creatinine clearance persisted indicating chronic renal damage. CONCLUSION: The present case is remarkable in that chronic renal damage due to intake of a compound analgesic was already observed in an 18-year-old patient. In this context, the permission of NSAID compound analgesics and their free over-the-counter sale to adolescents need to be critically questioned.
|
Authors | Eric Jochum, Ulf Janssen |
Journal | Medizinische Klinik (Munich, Germany : 1983)
(Med Klin (Munich))
Vol. 101
Issue 10
Pg. 830-4
(Oct 15 2006)
ISSN: 0723-5003 [Print] Germany |
Vernacular Title | Chronisch-interstitielle Nephritis bei einem 18-Jährigen durch Einnahme eines Mischanalgetikums. |
PMID | 17039326
(Publication Type: Case Reports, English Abstract, Journal Article)
|
Chemical References |
- Anti-Inflammatory Agents, Non-Steroidal
- Drug Combinations
- Acetaminophen
- Caffeine
- Creatinine
- Aspirin
|
Topics |
- Acetaminophen
(administration & dosage, toxicity)
- Adolescent
- Anti-Inflammatory Agents, Non-Steroidal
(administration & dosage, toxicity)
- Aspirin
(administration & dosage, toxicity)
- Biopsy
- Caffeine
(administration & dosage, toxicity)
- Creatinine
(blood)
- Drug Combinations
- Flank Pain
(etiology)
- Headache
(drug therapy)
- Humans
- Kidney
(pathology)
- Kidney Failure, Chronic
(chemically induced, diagnosis, pathology)
- Male
- Nephritis, Interstitial
(chemically induced, diagnosis, pathology)
- Urography
|