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[Relationship between single nucleotide polymorphisms of NRAMP1 gene and susceptibility to pulmonary tuberculosis in workers exposed to silica dusts].

AbstractOBJECTIVE:
To explore the relationship between polymorphisms of natural resistance-associated macrophage protein 1 (NRAMP1) gene and genetic susceptibility of pulmonary tuberculosis (PTB) in workers exposed to silica dusts.
METHODS:
A 1:2 case control study of 61 male workers with PTB (50 silicosis patients and 11 unsilicosis workers) as the case group and 122 male PTB-free workers (100 silicosis patients and 22 unsilicosis workers) as the control group was conducted with the frequency matched for age of +/- 5 years, the job, the silica exposure, and the condition of cigarette smoking and alcohol drinking. The polymerase chain reaction-restrained fragment length polymorphism technique (PCR-RFLP) was used to detect the single nucleotide polymorphisms (SNPs) of NRAMP1 INT4 and D543N.
RESULTS:
There was a 2.73 times (95% CI: 1.32 approximately 5.64) increased risk of silicosis for individuals with C allele of NRAMP1 INT4 compared with individuals carrying homozygote (G/G), while SNPs of NRAMP1 D543N was not associated with PTB (P > 0.05).
CONCLUSION:
The G > C mutation of intron 4 of NRAMP1 gene might be a susceptible factor of silica for the workers exposed to PTB.
AuthorsYa-bin Qu, Yun-xia Tang, Zhong-bin Zhang, Ren Zhu, Jing Liu, Shou-yong Gu, Guo-liang Lu, Zhao-lin Xia
JournalZhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases (Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi) Vol. 24 Issue 9 Pg. 531-3 (Sep 2006) ISSN: 1001-9391 [Print] China
PMID17034726 (Publication Type: English Abstract, Journal Article)
Chemical References
  • Cation Transport Proteins
  • natural resistance-associated macrophage protein 1
Topics
  • Aged
  • Alleles
  • Case-Control Studies
  • Cation Transport Proteins (genetics)
  • Genetic Predisposition to Disease
  • Humans
  • Middle Aged
  • Polymerase Chain Reaction
  • Polymorphism, Restriction Fragment Length
  • Silicosis (complications)
  • Tuberculosis, Pulmonary (complications, genetics)

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