Abstract | OBJECTIVE: METHODS: A 1:2 case control study of 61 male workers with PTB (50 silicosis patients and 11 unsilicosis workers) as the case group and 122 male PTB-free workers (100 silicosis patients and 22 unsilicosis workers) as the control group was conducted with the frequency matched for age of +/- 5 years, the job, the silica exposure, and the condition of cigarette smoking and alcohol drinking. The polymerase chain reaction-restrained fragment length polymorphism technique (PCR-RFLP) was used to detect the single nucleotide polymorphisms (SNPs) of NRAMP1 INT4 and D543N. RESULTS: There was a 2.73 times (95% CI: 1.32 approximately 5.64) increased risk of silicosis for individuals with C allele of NRAMP1 INT4 compared with individuals carrying homozygote (G/G), while SNPs of NRAMP1 D543N was not associated with PTB (P > 0.05). CONCLUSION: The G > C mutation of intron 4 of NRAMP1 gene might be a susceptible factor of silica for the workers exposed to PTB.
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Authors | Ya-bin Qu, Yun-xia Tang, Zhong-bin Zhang, Ren Zhu, Jing Liu, Shou-yong Gu, Guo-liang Lu, Zhao-lin Xia |
Journal | Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases
(Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi)
Vol. 24
Issue 9
Pg. 531-3
(Sep 2006)
ISSN: 1001-9391 [Print] China |
PMID | 17034726
(Publication Type: English Abstract, Journal Article)
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Chemical References |
- Cation Transport Proteins
- natural resistance-associated macrophage protein 1
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Topics |
- Aged
- Alleles
- Case-Control Studies
- Cation Transport Proteins
(genetics)
- Genetic Predisposition to Disease
- Humans
- Middle Aged
- Polymerase Chain Reaction
- Polymorphism, Restriction Fragment Length
- Silicosis
(complications)
- Tuberculosis, Pulmonary
(complications, genetics)
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