[Colonic perforation in a patient treated with combination chemotherapy for recurrent ovarian clear cell adenocarcinoma].

Abstract

BACKGROUND:

Colonic perforation due to colitis is a known and reported side effect of chemotherapy.

CASE REPORT:

A 53-year-old woman was treated with combination chemotherapy of irinotecan plus cisplatin for a recurrent ovarian clear cell adenocarcinoma. Steroid was also used for suspected interstitial pneumonia. After two cycles of treatment, she developed a colonic perforation. Emergency laparotomy was not performed because of poor performance status with multiple lung metastases, pleural effusion and pericardial effusion. Colonoscopy showed a perforated wall at the cecum, and a long tube with balloon was inserted for occlusion. In addition, a peritoneal drainage tube was inserted. Oral intake could be restarted for a while, but she died from tumor progression one and a half months after the diagnosis of perforation.

CONCLUSION:

Non-surgical management with peritoneal drainage and ileus tube was useful in this case of colonic perforation for preserving oral intake and quality of life.

• Authors: Kohei Shitara, Masaki Munakata, Atsushi Ishiguro, Toshihiro Kudo, Ritsuko Okada, Rumiko Tomioka, Sumako Mitobe, Shin Yokoyama, Yuh Sakata
• Journal: Gan to kagaku ryoho. Cancer & chemotherapy (Gan To Kagaku Ryoho) Vol. 33 Issue 10 Pg. 1497-1500 (Oct 2006) ISSN: 0385-0684 [Print] Japan
• PMID: 17033246 (Publication Type: Case Reports, Journal Article)

Chemical References

• Irinotecan
• Cisplatin
• Camptothecin

Topics

• Adenocarcinoma, Clear Cell (drug therapy, secondary)
• Antineoplastic Combined Chemotherapy Protocols (adverse effects, therapeutic use)
• Camptothecin (administration & dosage, analogs & derivatives)
• Cecal Diseases (diagnosis, etiology)
• Cisplatin (administration & dosage)
• Colonoscopy
• Drainage
• Drug Administration Schedule
• Fatal Outcome
• Female
• Humans
• Intestinal Perforation (diagnosis, etiology, therapy)
• Irinotecan
• Lung Neoplasms (secondary)
• Middle Aged
• Neoplasm Recurrence, Local (drug therapy)
• Ovarian Neoplasms (drug therapy, pathology)
• Pleural Effusion, Malignant (etiology)