Abstract | BACKGROUND:
Atopic dermatitis (AD) is aggravated by mechanical irritation and bacterial colonization. OBJECTIVE: This study compared the efficacy of an antimicrobial silk fabric (DermaSilk) with that of a topical corticosteroid in the treatment of AD. METHODS: Fifteen children were enrolled and wore a dress, where the left side was made of DermaSilk and the right side was made of cotton. The right arm and leg were treated daily with the corticosteroid mometasone for 7 days. The treatment efficacy was measured with a modified EASI ( Eczema Area and Severity Index) and with an assessment by the patients/parents and by a physician. All patients were evaluated at baseline, as well as 7 and 21 days after the initial examination. RESULTS: All parameters showed that, irrespective of the treatment, there was a significant decrease of eczema after 7 days. No significant difference between DermaSilk-treated and corticosteroid-treated skin could be observed. CONCLUSION: DermaSilk showed potential to become an effective treatment of AD.
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Authors | G Senti, L S Steinmann, B Fischer, R Kurmann, T Storni, P Johansen, P Schmid-Grendelmeier, B Wuthrich, T M Kundig |
Journal | Dermatology (Basel, Switzerland)
(Dermatology)
Vol. 213
Issue 3
Pg. 228-33
( 2006)
ISSN: 1018-8665 [Print] Switzerland |
PMID | 17033173
(Publication Type: Comparative Study, Journal Article)
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Chemical References |
- Anti-Allergic Agents
- Anti-Bacterial Agents
- Pregnadienediols
- Silk
- Mometasone Furoate
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Topics |
- Administration, Cutaneous
- Anti-Allergic Agents
(administration & dosage)
- Anti-Bacterial Agents
(therapeutic use)
- Child
- Child, Preschool
- Clothing
- Colony Count, Microbial
- Dermatitis, Atopic
(etiology, prevention & control)
- Eczema
(drug therapy)
- Female
- Humans
- Infant
- Male
- Microbial Sensitivity Tests
- Mometasone Furoate
- Pregnadienediols
(administration & dosage)
- Silk
- Staphylococcal Skin Infections
(etiology, prevention & control)
- Staphylococcus aureus
(drug effects, growth & development)
- Treatment Outcome
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