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Antimicrobial silk clothing in the treatment of atopic dermatitis proves comparable to topical corticosteroid treatment.

AbstractBACKGROUND:
Atopic dermatitis (AD) is aggravated by mechanical irritation and bacterial colonization.
OBJECTIVE:
This study compared the efficacy of an antimicrobial silk fabric (DermaSilk) with that of a topical corticosteroid in the treatment of AD.
METHODS:
Fifteen children were enrolled and wore a dress, where the left side was made of DermaSilk and the right side was made of cotton. The right arm and leg were treated daily with the corticosteroid mometasone for 7 days. The treatment efficacy was measured with a modified EASI (Eczema Area and Severity Index) and with an assessment by the patients/parents and by a physician. All patients were evaluated at baseline, as well as 7 and 21 days after the initial examination.
RESULTS:
All parameters showed that, irrespective of the treatment, there was a significant decrease of eczema after 7 days. No significant difference between DermaSilk-treated and corticosteroid-treated skin could be observed.
CONCLUSION:
DermaSilk showed potential to become an effective treatment of AD.
AuthorsG Senti, L S Steinmann, B Fischer, R Kurmann, T Storni, P Johansen, P Schmid-Grendelmeier, B Wuthrich, T M Kundig
JournalDermatology (Basel, Switzerland) (Dermatology) Vol. 213 Issue 3 Pg. 228-33 ( 2006) ISSN: 1018-8665 [Print] Switzerland
PMID17033173 (Publication Type: Comparative Study, Journal Article)
Chemical References
  • Anti-Allergic Agents
  • Anti-Bacterial Agents
  • Pregnadienediols
  • Silk
  • Mometasone Furoate
Topics
  • Administration, Cutaneous
  • Anti-Allergic Agents (administration & dosage)
  • Anti-Bacterial Agents (therapeutic use)
  • Child
  • Child, Preschool
  • Clothing
  • Colony Count, Microbial
  • Dermatitis, Atopic (etiology, prevention & control)
  • Eczema (drug therapy)
  • Female
  • Humans
  • Infant
  • Male
  • Microbial Sensitivity Tests
  • Mometasone Furoate
  • Pregnadienediols (administration & dosage)
  • Silk
  • Staphylococcal Skin Infections (etiology, prevention & control)
  • Staphylococcus aureus (drug effects, growth & development)
  • Treatment Outcome

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